MTHFR C677T and A1298C reduce enzyme activity by up to 70% in homozygotes, impairing conversion of folic acid to 5-methyltetrahydrofolate. This directly affects B12 utilization, homocysteine clearance, and DNA methylation capacity — the most impactful and testable supplement genetics finding.
VDR (receptor) and GC (binding protein) variants determine how efficiently vitamin D is activated, transported, and utilized. Low-function genotypes require significantly higher supplemental doses to reach optimal serum levels — a straightforward, clinically actionable finding.
SOD2 (superoxide dismutase) and CAT (catalase) variants reduce cellular antioxidant enzyme activity — increasing oxidative stress load and the benefit derived from dietary and supplemental antioxidants. The genetic case for or against high-dose antioxidant supplementation.
Low-activity FADS variants impair the conversion of plant-based ALA to the long-chain EPA and DHA used by the brain and cardiovascular system. This makes marine-source or algae-based omega-3 supplementation physiologically necessary, not optional, for affected genotypes.
Variants in TRPM6 and TRPM7 affect magnesium reabsorption in the kidney and intestinal uptake — determining baseline magnesium status independent of dietary intake. The genetic baseline for a mineral that influences sleep, blood pressure, and muscle function.
HFE variants (C282Y, H63D) affect hepcidin regulation and iron absorption — covering both the clinically significant hemochromatosis risk and the supplementation-relevant iron absorption efficiency that affects athletic performance and energy levels.
Structured need assessment for each major supplement category — B vitamins, vitamin D, omega-3s, antioxidants, magnesium, iron, and more. Based on the specific genetic variants that determine whether supplementation is likely to produce measurable benefit.
Where genetics affects which supplement form is absorbed or utilized — methylfolate vs folic acid, cholecalciferol vs ergocalciferol, marine vs plant omega-3 — the GeneOps engine surfaces form-specific recommendations rather than generic dosing guidance.
Ranked supplement priorities by genetic need — so users and clinicians know which supplements are addressing a genuine genetic insufficiency and which are likely redundant. A framework for cutting through supplement noise with biological precision.
Supplement recommendations connect seamlessly with the nutrition, fitness, sleep, and mental health domains — ensuring that supplement protocols are coherent across the user's full genetic profile rather than domain-isolated recommendations.
Whether you're a supplement company, a personalized nutrition platform, or a wellness product that wants to move beyond generic recommendations — let's talk about what genomic intelligence looks like in your context.