IL6 and TNF are master regulators of the acute inflammatory response. Promoter variants in these genes determine baseline inflammatory tone and the magnitude of cytokine release in response to infection, exercise, and metabolic stress. High-production variants associate with elevated chronic inflammation — "inflammaging" — and differential response to anti-inflammatory interventions.
Toll-like receptors (TLR2, TLR4) are the innate immune system's first-line pathogen recognition proteins. Functional variants affect the sensitivity and magnitude of the innate immune response — determining individual variation in susceptibility to bacterial and viral infection and the inflammatory severity of immune activation events.
The HLA (human leukocyte antigen) region carries the strongest genetic associations with autoimmune disease risk of any locus in the genome. HLA typing provides risk context for conditions including rheumatoid arthritis, type 1 diabetes, ankylosing spondylitis, and celiac disease — each with directly actionable lifestyle and monitoring implications.
Vitamin D is a potent immune modulator — directly regulating T-cell differentiation, macrophage activity, and antimicrobial peptide production. VDR variants affect immune responsiveness to vitamin D signaling — determining how much benefit immune function receives from vitamin D optimization and how high supplemental doses need to be to achieve immunological effects.
Immune cells generate reactive oxygen species during infection response. SOD2 and GPX1 variants determine the efficiency of antioxidant protection within immune cells — affecting immune cell longevity, inflammatory resolution, and the degree to which oxidative stress from immune activation damages surrounding tissue.
PTPN22 and CTLA4 regulate T-cell activation thresholds. Variants in these genes are among the most replicated common genetic risk factors for autoimmune conditions — affecting the stringency of the thymic self-tolerance mechanism and the likelihood that immune cells mistakenly target self-antigens.
A structured multi-variant inflammatory assessment — IL6, TNF, CRP, and related pathway variants combined into an actionable inflammatory risk profile. Directly informs anti-inflammatory dietary patterns, omega-3 dosing, and exercise protocols for inflammatory load management.
Genotype-specific immune support protocols — vitamin D dosing based on VDR status, zinc and selenium needs, elderberry and mushroom adaptogen responsiveness, and probiotics for gut-immune axis optimization. Each recommendation grounded in the user's specific immune genetics.
HLA and immune regulation variant profiling providing a genetic autoimmune risk context. Not a diagnostic — a calibrated risk profile that informs monitoring priorities, symptom awareness, and the urgency of specialist engagement when relevant symptoms arise.
Immune genetics connected to the longevity domain — "inflammaging" is one of the core mechanisms of biological aging. The immune health profile integrates with the longevity domain to provide a complete picture of inflammatory aging risk and the interventions most likely to slow it.
Whether you're building a longevity platform, an immune health product, or a clinical tool — let's discuss what immune genomic intelligence adds to your personalization approach.